T­-Cell Immunotherapy for Brain Tumors: Using CAR Technology for Glioblastoma


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Neurosurgeon Donald M. O’Rourke, MD, discusses recent developments in post­surgical immunological therapy for glioblastomas. Dr O’Rourke reviews brain cancer vaccine trials at Penn Medicine, focusing on the EGFRvIII peptide vaccine, offers a synopsis of the application at Penn of adoptive T cell therapy to the brain cancers and considers GBM­-surface antigens for CAR therapy in glioma.


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