Maximal Tolerated Dose I-131 Therapy for Advanced Thyroid Cancer and Determination of Iodine Refractory Disease


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In this presentation, David A Mankoff, MD, PhD, examines a variety of interrelated topics-the use of iodine dosimetry to calculate a maximum tolerated dose for I-131 in metastatic thyroid cancer and patients with altered iodine clearance; the avoidance of bone and hematological toxicity; I-131 therapy using recombinant TSH stimulation versus thyroid hormone; and the ways and means to define iodine refractory disease in patients with progressing thyroid cancer.


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