Carl June, MD: The Promise and Challenges of CAR T-Cell Therapy for Pancreatic Cancer (2019)

Video

Carl June, MD: The Promise and Challenges of CAR T-Cell Therapy for Pancreatic Cancer (2019)

Published: May 22, 2019

Carl June, MD: The Promise and Challenges of CAR T-Cell Therapy for Pancreatic Cancer (2019)

Overview

In the early years of studying immunotherapy at Penn Medicine, our high hopes for an immunological breakthrough in pancreatic cancer were frustrated by the cancer’s unique capacity to resist immune system interventions.

However, new research at Penn’s Abramson Cancer Center is beginning to shed light on the once intractable mechanisms of pancreatic cancer.

In this video, CAR-T pioneer Carl June, MD, explains the innate challenges he encountered when using immunotherapies to treat pancreatic cancer. Dr. June also reviews the potential of anti-tumor mesothelin-specific CAR-T cell therapy in metastatic pancreatic ductal adenocarcinoma (PDA), which is now being investigated through clinical trials at Penn.

Related Links

Pancreatic Cancer: Associated Signs, Symptoms, Risk Factors and Treatment Approaches
CAR-T Cell Therapy: A Breakthrough Treatment for Fighting Cancer
Immunotherapy for Pancreatic CancerImmunology and Immunotherapy for Pancreatic Cancer | A Penn Medicine CME
Enrolling Clinical Trials: Rucaparib for the Treatment of Pancreatic Cancer Immunotherapy for Pancreatic Cancer
Enrolling Clinical Trials: Combination Chemotherapy / Immunotherapy for Patients With Previously Untreated Metastatic Pancreatic Ductal Adenocarcinoma
Twitter @PennMDForum
Dr. June’s physician profile
Dr. Lee’s physician profile
Dr. Vonderheide’s physician profile

Published

May 22, 2019

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Alison Loren, MD, reports on survivorship among patients following autologous and allogeneic hematopoietic cell transplantation.

Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia

Anthony Mato, MD, provides in update from ASH 2015 on the shift from chemoimmunotherapy to the kinase inhibitors for the front-line management of chronic lymphocytic leukemia.

What’s Next for Melanoma Immunotherapy?

What’s Next for Melanoma Immunotherapy?

Renowned cancer researcher Robert Vonderheide, MD, Phil, the Hanna Wise Professor in Cancer Research at Penn Medicine, discusses the present and future of melanoma therapy

What’s new in Blood and Bone Marrow Transplantation?

What’s new in Blood and Bone Marrow Transplantation?

Saar Gill, MD, PhD, discusses the current status of blood and marrow transplantation

Therapeutic Strategies for the Newly Diagnosed Multiple Myeloma Patient

Therapeutic Strategies for the Newly Diagnosed Multiple Myeloma Patient

Edward Stadtmauer, MD, provides an overview of current studies and regimens for patients with newly diagnosed multiple myeloma.

Cellular Therapies: Revolutionizing Cancer Therapy, Part 4: Adoptive Cell Therapy - Lessons Learned, Issues and the Future

Cellular Therapies: Revolutionizing Cancer Therapy, Part 4: Adoptive Cell Therapy - Lessons Learned, Issues and the Future

Carl June, MD, reviews the challenges identified with CAR T cell therapy in the hematologic malignancies, possibilities for their resolution and the future of the therapy.

$Cellular Therapies: Revolutionizing Cancer Therapy, Part 3: CTL019 in Relapsed Refractory Pediatric Acute Lymphoblastic Leukemia$ Video

Cellular Therapies: Revolutionizing Cancer Therapy, Part 3: CTL019 in Relapsed Refractory Pediatric Acute Lymphoblastic Leukemia

In this video, Carl June, MD, reflects on the case of Emily Whitehead, the first pediatric patient treated with CAR T cell therapy for pediatric relapsed, refractory ALL --and her four years in complete remission.

Cellular Therapies: Revolutionizing Cancer Therapy, Part 2: CTL019 Therapy in Chronic Lymphocytic Leukemia

Cellular Therapies: Revolutionizing Cancer Therapy, Part 2: CTL019 Therapy in Chronic Lymphocytic Leukemia

Carl H June, MD, reviews the phase 1 study of CTL019 (CAR T) therapy in patients with refractory, relapsed chronic lymphocytic leukemia.

Cellular Therapies: Revolutionizing Cancer Therapy, Part 1: Adoptive Cell Therapy - An Introduction

Cellular Therapies: Revolutionizing Cancer Therapy, Part 1: Adoptive Cell Therapy - An Introduction

Dr. Carl June introduces the adoptive cell therapies for hematologic cancers and discusses the optimal approaches to CAR T cell therapy.

Inside the Center for Personalized Diagnostics

Inside the Center for Personalized Diagnostics

Wonder how precision medicine works? This video gives an inside look at genomic cancer testing at Penn Medicine's Center for Personalized Diagnostics.

Nipple Tattoos after a Mastectomy

Nipple Tattoos after a Mastectomy

Dr. Serletti reviews Penn’s offering of nipple tattoos to breast cancer survivors after mastectomy to help their sense of femininity on the path to recovery.

Recent Advances in Oncology: What’s New in Surgery

Recent Advances in Oncology: What’s New in Surgery

Thoracic surgeon Taine T.V. Pechet, MD, provides an overview of recent advances in thoracic surgery and rehabilitative care at Penn Medicine.

Early Detection of Mesothelioma

Early Detection of Mesothelioma

Anil Vachani, MD, examines the challenges and methods of early mesothelioma detection.

Quality of Life and Neurocognitive Function in Brain Tumor Survivors

Quality of Life and Neurocognitive Function in Brain Tumor Survivors

Neuropsychologist Carol Armstrong, PhD, presents the spectrum of cognitive, psychological, emotional and physical effects that confront the survivors of brain tumor treatment.

Metabolomics and IDH1: Potential Therapeutic Targets to Block Glioma in Progression

Metabolomics and IDH1: Potential Therapeutic Targets to Block Glioma in Progression

Abramson Center Director Chi Van Dang, MD, PhD, reviews the metabolic impact of cancer-associated IDH1 mutations in the gliomas and efforts to block IDH1 and thus halt the progression of these lesions.

ABCs of Cancer Immunology: What a Practicing Oncologist Needs to Know

ABCs of Cancer Immunology: What a Practicing Oncologist Needs to Know

Gregory L. Beatty, MD, PhD, brings his insight to a comprehensive overview of cancer immunotherapy.

Management of Patients Receiving Immune Therapy

Management of Patients Receiving Immune Therapy

Optimizing the care of patients receiving immune therapy.

Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia

Anthony R. Mato, MD, outlines recent clinical advances in therapy for patients with chronic lymphocytic leukemia.

Re-Irradiation of Primary Brain Tumors

Re-Irradiation of Primary Brain Tumors

Robert Lustig, MD, discusses the evolving concept of re-irradiation of primary brain tumors.

Molecular Profiling in the Diagnosis of Gliomas

Molecular Profiling in the Diagnosis of Gliomas

Maria Martinez-Lage, MD, discusses the four subtypes of glioblastoma and discusses efforts at the Penn Center for Personalized Diagnostics to expand the genetic profile for the disease.

Fluorescent-Guided Brain Tumor Resection

Fluorescent-Guided Brain Tumor Resection

John Y.K. Lee, MD, offers the insight of a practicing neurosurgeon to the use of fluorescent dyes to enhance the visualization of brain tumors.

T-Cell Immunotherapy for Brain Tumors: Using CAR Technology for Glioblastoma

T-Cell Immunotherapy for Brain Tumors: Using CAR Technology for Glioblastoma

Neurosurgeon Donald O’Rourke, MD, reviews CAR Technology and other immunological approaches to the treatment of brain tumors.

Proton Therapy for Low-Grade Gliomas

Proton Therapy for Low-Grade Gliomas

Robert Lustig, MD, offers an overview of the application of proton therapy to low-grade gliomas at the Roberts Proton Therapy Center at Penn Medicine.

New Aspects of Tyrosine Kinase Inhibitors

New Aspects of Tyrosine Kinase Inhibitors

Marcia Brose, MD, discusses the treatment of radioiodine-refractory differentiated thyroid cancer with the kinase inhibitors sorafenib and lenvatinib.

$Approved: Sorafenib and Lenvatinib for the Treatment of Progressive, RAI-Refractory DTC$ Video

Approved: Sorafenib and Lenvatinib for the Treatment of Progressive, RAI-Refractory DTC

Marcia Brose, MD, discusses the treatment of radioiodine-refractory differentiated thyroid cancer with the kinase inhibitors sorafenib and lenvatinib.

$Maximal Tolerated Dose I-131 Therapy for Advanced Thyroid Cancer and Determination of Iodine Refractory Disease$ Video

Maximal Tolerated Dose I-131 Therapy for Advanced Thyroid Cancer and Determination of Iodine Refractory Disease

Daniel Pryma, MD, offers an overview of the distinguishing features of radioiodine-refractory thyroid cancer.

Surgery for Advanced and Recurrent Differentiated Thyroid Cancer

Surgery for Advanced and Recurrent Differentiated Thyroid Cancer

Ara Chalian, MD, discusses the role and challenges of surgery in the treatment of advanced and recurrent thyroid cancer.

Penn Precision Medicine: The Link to Radiology

Penn Precision Medicine: The Link to Radiology

Mitchell Schnall, MD, provides an overview of the interaction between the Department of Radiology and the Precision Medicine Program at Penn Medicine.

Pathology and Laboratory Medicine

Pathology and Laboratory Medicine

Precision Medicine Treating the right patient, at the right time, with the right treatment. David B. Roth, MD, PhD, Chair, Department of Pathology and Laboratory Medicine and Director of the Precision Medicine Program, discusses the ...

Katherine Nathanson, MD, discusses the importance of oncogenomics for cancer sequencing and screening protocols for cancer screening.

The Role of Bioinformatics in Precision Medicine

The Role of Bioinformatics in Precision Medicine

In this video, Jason Moore, PhD, outlines the role of bioinformatics as a component of precision medicine and its valuable part in the diagnosis and treatment choices for patients with serious disease.

Practical Applications in Lung Cancer

Practical Applications in Lung Cancer

Corey Langer, MD, provides an overview of the advantages that precision medicine confers on patients whose cancers are found to have treatable genetic aberrations.

The Future of Medicine

The Future of Medicine

In this video, the directors and faculty of the Precision Medicine Program at Penn Medicine provide an overview of precision medicine and its role in the management of serious disease.

Recent Advances in Gastrointestinal Cancers

Recent Advances in Gastrointestinal Cancers

Ursina Teitelbaum, MD, provides an overview of reports from ASCO on the current state of targeted therapies for the gastrointestinal cancers.

Update in MGUS, SMM and AL Amyloidosis, Part 2: Monoclonal Gammopathy and Amyloidosis

Update in MGUS, SMM and AL Amyloidosis, Part 2: Monoclonal Gammopathy and Amyloidosis

Brendan Weiss, MD, considers the early diagnosis of AL amyloidosis and the potential for current therapy to improve outcomes in advanced disease

Update in MGUS, SMM and AL Amyloidosis, Part 1: Smoldering Multiple Myeloma

Update in MGUS, SMM and AL Amyloidosis, Part 1: Smoldering Multiple Myeloma

Brendan Weiss, MD, reviews the diagnosis of smoldering multiple myeloma in the context of progression to symptomatic disease

Experimental Therapies for Relapsed Myeloma

Experimental Therapies for Relapsed Myeloma

Dan Vogl, MD, discusses the current state of drug therapy for relapsing and recurrent multiple myeloma

Latest Transplant Approaches for Myeloma

Latest Transplant Approaches for Myeloma

Adam D. Cohen, MD, reviews what’s new in clinical studies for stem cell transplantation in multiple myeloma

Genetically Engineered T-cells for B Cell Malignancies

Genetically Engineered T-cells for B Cell Malignancies

In this video, David L. Porter, MD, describes CAR T immunotherapy for the treatment of the B cell malignancies, including acute and chronic lymphocytic leukemia.

Highlights on Better Therapies for Melanoma

Highlights on Better Therapies for Melanoma

Renowned melanoma specialist and researcher Lynn Schuchter, MD, offers her unique perspective on the most recent advances in drug therapy for melanoma.

Blood Cancer Update: New Insights for the Future

Blood Cancer Update: New Insights for the Future

Edward A. Stadtmauer, MD, provides a comprehensive update on the latest advances in the therapeutic profile of the hematological malignancies.

Update in Oncology: Breast Cancer Summary

Update in Oncology: Breast Cancer Summary

Breast cancer specialist Kevin R. Fox, MD, reviews breast cancer therapy with a focus on early stage disease.

Update on Genitourinary Cancers

Update on Genitourinary Cancers

David Vaughn, MD, considers the genitourinary cancers as reflected in recent reports from ASCO.

Personalized Medicine and the Future of Pathology at Penn Medicine

Personalized Medicine and the Future of Pathology at Penn Medicine

David B. Roth, MD, PhD, offers an overview of the Center for Personalized Diagnostics (CPD), where pathologists are performing large-scale, massively parallel DNA sequencing and chromosomal analysis

Case Studies in the Myeloproliferative Neoplasms

Case Studies in the Myeloproliferative Neoplasms

Elizabeth Hexner, MD, MS, presents four case studies representing patients with the myeloproliferative disorders polycythemia vera, thrombocythemia, mast cell disease and myelofibrosis.

New Therapies and Current Management of Lymphomas

New Therapies and Current Management of Lymphomas

Stephen J. Schuster, MD, discusses the latest advances in clinical research for the treatment of the lymphomas as presented at the American Society of Hematology (ASH) meeting in 2013.

Curing Cancer: The Philadelphia Award and Dr. Carl June

Curing Cancer: The Philadelphia Award and Dr. Carl June

In 2013, Carl June, MD, won the Philadelphia Award for his pioneering work in the use of engineered chimeric antigen-modified T cells to treat acute lymphoid leukemia and chronic lymphocytic leukemia.

Targeted Cellular Therapy in Blood Cancers | CTL019 for Leukemia

Targeted Cellular Therapy in Blood Cancers | CTL019 for Leukemia

Hematologist-Oncologist David L. Porter, MD, presents on the pioneering use of CTL-019 (formerly CART-19) at Penn Medicine for adoptive immunotherapy in patients with relapsed or chemotherapy-refractory chronic lymphocytic leukemias (CLL).

Emerging Treatment Options for the Myelodysplastic Syndromes

Emerging Treatment Options for the Myelodysplastic Syndromes

Noelle Frey, MD, a hematologist-oncologist at Penn Medicine and the Abramson Cancer Center, presents a summary of approaches to the myelodysplastic syndromes with a focus upon improved prognosis and the application of novel drug therapies.

Lower-Grade Monoclonal Protein-Related Diseases

Lower-Grade Monoclonal Protein-Related Diseases

Brendan Weiss, MD, offers an overview of treatment and prognostic considerations for the monoclonal protein-related diseases with a focus on monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma and AL amyloidosis.

Center for Personalized Diagnostics - Precision Diagnostics

Center for Personalized Diagnostics - Precision Diagnostics

David Roth, MD, PhD, describes the legacy and mission of the Center for Personalized Diagnostics (CPD), a joint effort of Penn Medicine and the Abramson Cancer Center.

Center for Personalized Diagnostics - Genomic Profiles for Melanoma

Center for Personalized Diagnostics - Genomic Profiles for Melanoma

Lynn M. Schuchter, MD, and her team at the Abramson Cancer Center at Penn Medicine are turning to the Center for Personalized Diagnostics to render genomic profiles for melanoma.

Update in Acute Leukemia

Update in Acute Leukemia

Director of the Leukemia Program at the Abramson Cancer Center and Penn Medicine, Selina Luger, MD, presents an overview of the past and current state of therapy for the leukemias and the improving prognosis for patients with the disease.

Experimental Treatments for Acute Leukemia

Experimental Treatments for Acute Leukemia

James K Mangan, MD, PhD, discusses investigational approaches to the treatment of acute leukemia and provides a review of standards for AML and ALL, as well as such novel therapies as the TKIs FLT3-ITD and dasantinib, gemtuzumab, CTL-019 and blinatumomab.

Update in Hematology: Graft-versus-Host Disease

Update in Hematology: Graft-versus-Host Disease

David L. Porter, MD discusses the treatment algorithims in use at Penn Medicine and the Abramson Cancer Center to minimize the effects of graft-versus-host disease, one of the severe and debilitating effects of chemotherapy in patients ...

Therapeutic Advances in Hodgkin Lymphoma

Therapeutic Advances in Hodgkin Lymphoma

Oncologist Jakub Svoboda, MD, offers an overview of recent advances in the treatment of Hodgkin Lymphoma, including new biological and targeted agents, optimal combinations and the evolving concept of limiting therapy.

Personalized Diagnostics in Acute Myeloid Leukemia

Personalized Diagnostics in Acute Myeloid Leukemia

This video features hematologist/oncologist Selina Luger, MD, discussing the role of mutational analysis in the prognosis of acute myeloid leukemia.

Mutational Analysis in Non-Small Cell Lung Cancer

Mutational Analysis in Non-Small Cell Lung Cancer

In this video, oncologist Corey Langer, MD, offers a broad overview of clinical trials of new agents for the treatment of non-small cell lung cancer and new targeted therapies for the disease.

Impact of Center for Personalized Diagnostics (CPD) Genomic Testing

Impact of Center for Personalized Diagnostics (CPD) Genomic Testing

This video provides a succinct examination of the Center for Personalized Diagnostics at Penn Medicine, its capabilities and clinician users.

Personalized Diagnostics in Melanoma

Personalized Diagnostics in Melanoma

Lynn Schuchter, MD, Chief, Division of Hematology/Oncology at Penn Medicine, discusses the advantages and challenges of personalized diagnostics in melanoma therapy.

Genomics and Clinical Trials How might this work? Biological, logistical and cultural challenges

Genomics and Clinical Trials How might this work? Biological, logistical and cultural challenges

In this video, Roger B. Cohen, MD, considers the challenge inherent in the vast amount of data arising from genomic testing from the perspective of a practicing oncologist, and how the profession might put this data to its best use in the future.

Proton Therapy for Breast Cancer

Proton Therapy for Breast Cancer

Radiation oncologist Gary M. Freedman, MD, discusses multidisciplinary care and the variety of innovative treatments (including proton therapy and clinical trials of investigational therapies) available to women with breast cancer at Penn ...

Diagnosis and Surgical Management of Pheochromocytomas

Diagnosis and Surgical Management of Pheochromocytomas

Dr. Giorgos Karakousis compares surgical techniques for pheochromocytomas and paragangliomas, including laprascopic surgery and traditional surgery, at the Focus on Neuroendocrine Tumors Conference.

Immunotherapy for Pancreatic Cancer

Immunotherapy for Pancreatic Cancer

In this summary, Robert H. Vonderheide, MD, DPhil, offers an overview of recent advances at Penn Medicine in immunological therapy for pancreatic cancer based upon antibodies that activate the patient's immune system

Genetically Modified T Cells for Chronic Lymphocytic Leukemia

Genetically Modified T Cells for Chronic Lymphocytic Leukemia

Carl June, MD, Director of Translational Research at the Abramson Cancer Center, reports on recent research advances in the treatment of patients with chronic lymphocytic leukemia

Immunotherapy for Advanced Ovarian Cancer

Immunotherapy for Advanced Ovarian Cancer

Gynecological Oncologist Janos Tanyi, MD, discusses his philosophy of care for patients with gynecological cancers, and reviews the comprehensive array of treatments for these malignancies at Penn Medicine.

Mesothelioma - Diagnosis, Treatment & Survivorship

Mesothelioma - Diagnosis, Treatment & Survivorship

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