Exosomes as Biomarkers for Tissue Rejection in Transplant Recipients

 In this engaging video, Penn cardiac surgeon Prashanth Vallabhajosyula, MD, describes the discovery in his laboratory that exosomes provide a blood-bound biomarker for tissue rejection in transplant recipients, and thus a noninvasive alternative to biopsy in this population. Explaining the origin of his study––exosomes are intracellular structures in the blood known to undergo distinct changes under stress––Dr Vallabhajosyula offers an overview of the investigation and its demonstration that the tissues of transplant recipients release donor-specific exosomes into the peripheral blood and that these exosomes display distinct chemical and genetic changes in the wake of rejection.


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April 18, 2017

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