Advanced MR Spectroscopy and Perfusion to Detect Metabolism and Response to Therapy in Gliomas


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Suyash Mohan, MD, discusses the approaches to advanced MR spectroscopy taking place in the research setting at Penn Medicine. Illustrating his discussion with case images and high-resolution scans, Dr. Mohan examines the use at Penn of the 7 Tesla MRI scanner to detect IDH1 mutations in glioblastomas; whole brain 3-D Echo-Planar Spectroscopic Imaging (EPSI) to distinguish true progression from pseudoprogression; and MR perfusion to assess tumor metabolism and physiology as a determinant of prognosis and physiology in brain tumor patients.



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